Beetlejuice is a ghost from "The Neitherworld," the land of the dead - he's a trickster and a swindler, but underneath it all he has a big heart. His best friend Lydia is a very kind-hearted twelve-year-old living girl who's into goth.
Lydia is an outcast and Beetlejuice is pretty much the only who relates to her. Whenever Lydia shouts "Beetlejuice!" 3 times in a row, Beetlejuice appears. Together they made the perfect pair - her even-tempered and levelheaded, and him manic and hot under the collar.
Beetlejuice is the main and title character of the show,he is able to change shape, transform and conjure objects, teleport, and perform other feats of magic, although his powers can be reduced by various circumstances, such as encounters with Sandworm or when his head becomes separated from his body.
Lydia Deetz is established as being a creative, bright, sharp, yet eccentric young girl, but otherwise Lydia's unique outlook on life makes her stand out from most of the other school-girls, which leaves her feeling out of place and alone in the real world, finding it difficult to fit in well with most of her classmates,leading her to frequently visit and seek out reassurance with her closest best friend, Beetlejuice.
Lydia's friend from school. She is tall and has an overbite. Bertha loves to swoon over teen boys, read teen magazines and eat chips. Like Lydia she too shares a passion for anything strange and unusual. Beetlejuice refers to her as Burp.
Prudence is Lydia's other friend from school who is a lot smaller than Bertha. Like Lydia and Bertha, Prudence is interested in anything scary or gross, but Prudence doesn't like it if anything's too scary.
Percy is Lydia's pet cat, an animal so high-strung that he makes Charles look relaxed. Although Percy is most times a victim of Beetlejuice's pranks, he sometimes manages to take revenge on him, in more than one way.
Jacques LaLean is a French skeleton bodybuilder and neighbor of Beetlejuice. He pursues a dream of becoming a great bodybuilder, a mostly comedic endeavor as he has no muscles, nor a body to devote fitness to, a fact he is very aware of, but regardless, does not take into consideration.
Claire Brewster is Lydia's upperclass rival and Beetlejuice's second rival from school. Claire is not only egotistical and overtly vain, she is also cruel, unapologetic and incredibly obnoxious, and shows no redeeming values whatsoever; she also reacts very badly to anyone who is prettier than her.
The Monster's beloved and talented pet dog, one of Beetlejuice's favorite prank victims, and because of this he strongly dislike of him, but he has the same affection towards Lydia that Beetlejuice shares with. Poopsie's girlfriend is The Monstress Across the Street's dog Poopette..
Doomie is Beetlejuice and Lydia's convertible, neon-green-painted sentient car. Doomie is normally an affable and friendly creature, but due to the abnormal brain Beetlejuice gave him during his construction, Doomie transforms into a vicious "four-wheeled werewolf".